Perfil químico das flores de Erythroxylum e caracterização química das folhas de E. Tortuosum (Erythroxylaceae)

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Universidade Federal de Goiás


The Cerrado is known as the world’s richest savanna in biodiversity, but still little explored from the chemical view. Among the genus of plants found in this biome, there is Erythroxylum (Erythroxylaceae), which is known mostly for the tropane alkaloids metabolites. This work describes a comparative study of flowers chemical profile from E. campestre, E. suberosum e E. tortuosum, as well as the chemical study of E. tortuosum leaves. To obtain the chemical profile of flowers for the different species, the extracts were prepared in hexane, dichloromethane, ethyl acetate and methanol, which were analyzed by 1H NMR, HPLC UV/DAD and GC-MS. The data showed similar phytochemical composition in the species investigated, suggesting attendance of terpenes, flavonoids and alkaloids. The GC-MS analysis afforded to identify hydrocarbons, aldehydes and a phenolic derivative. The extracts of the leaves of E. tortuosum were prepared likewise the flowers extracts, but to obtain alkaloids it was performed an acid-base extraction of the methanolic extract of the leaves. From the ethyl acetate and methanolic extracts of leaves, were identified six substances: α-amyrin (I), β-amyrin (II), campesterol (III), stigmastan-3,5-diene (IV), β-sitosterol (V) and 7,4’-di-O-methylquercetin-3-O-β -rutinoside (IX), which flavonoid was found as the major compound of extracts. Through the alkaloid extraction it was possible to identify three tropane alkaloids: tropacocaine (VI), cocaine (VII) and 6-methoxy-8-methyl-8-azabicyclo[3.2.1]octan-3-ol (VIII), and among them, compound (VIII) was described for the first time in Erythroxylum genus. The results obtained are important for the chemical knowledge of the Cerrado biodiversity, since there are not much data in the literature about the species studied in this work.



Erythroxylum, Metabólitos secundários, Cerrado, Secondary metabolites, Cerrado, Erythroxylum


ALCHAAR, M. M. F. Perfil químico das flores de Erythroxylum e caracterização química das folhas de E. Tortuosum (Erythroxylaceae). 2018. 83 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Catalão, 2018.