Efeito de antagonista do receptor de leucotrienos na doença ulcerosa péptica

Abstract

Peptic ulcer (PU) is a common disease of the gastrointestinal tract that affects up to 20% of the world's population. Its treatment remains challenging due to the limited effectiveness and serious side effects of currently available drugs. Considering the high costs and speed of new drug development, drug repositioning, which consists of using already established drugs to treat other diseases, has been an alternative to accelerate the process of validating new therapies. Seeking to provide alternative drugs for the treatment of PU, the development of this study evaluated the gastroprotective effects of montelukast (MKT). The methodology will cover a) model of induction of acute gastric injury by ethanol; b) a model of induction of acute gastric injury by the non- steroidal anti-inflammatory drug (NSAID); c) the determination of antioxidant mechanisms by blocking sulfhydryl compounds (HS) in the gastric mucosa. In this study, MTK inhibited statistically significantly in the induced injury models at a dose of 15 mg/kg. In the presence of an HS blocker, MTK lost its gastroprotection, thus indicating that its mucosal protective effect is dependent on HS integrity. Ethanol and NSAID induced gastric damage and MTK neutralized the gastric lesions, probably by its effects antioxidant, anti-inflammatory, and inhibitor of neutrophil activation.