Estudo químico e avaliação biológica das espécies Byrsonima coccolobifolia Kunth. (malpighiaceae) e Eugenia malaccensis L. (myrtaceae)

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Universidade Federal de Goiás


The study described in this work contributed to the chemical and biological knowledge of species B. coccolobifoliaand E. malaccensis,known popularly as "murici" and "jambo-vermelho", respectively. These species are found in various regions of Brazil, especially in Cerrado areas, and are widely appreciated by ediblefruit. Several applications in folk medicine are related to these species,such as antibacterial activity, antidiarrheal, anti-inflammatory and on control diabetes (antidiabetic). The study of roots ethanolic extract of B. coccolobifolialed to the identification of mixture of triterpenes α-amiryn and β-amiryn, mixture of steroids campesterol, stigmasterol and β-sitosterol, oleanolic acid(olenene-type triterpene) and glochidonol (lupane-type triterpene), reported for the first time in the Byrsonima genus. Of the leaves ethanolic extract of E. malaccensiswas possible to isolate two flavonoids, mearnsetin and mearnsitrin, both of flavonol class. The structural identification was carried out on the basis of 1D- and 2D-NMR experiments, GC/MS and comparison with literature data. It was also measured the inhibition potential of extracts and your fractions of these plants against cathepsins K, V and L. These enzymes are found mainly in lysosomes and may also involved in selective and controlled pathological processes, such as cardiovascular diseases, osteoporosis, atherosclerosis, malignant, pancreatitis, many others. The extracts and most partitions showed considerable inhibition against cathepsins (concentration of 125 and 50 µg/mL), and the best results are observed for cathepsin V. The flavonoids mearnsetin and mearnsitrin have not presented activity when evaluated in cathepsins K and V (concentration of 25 µM).



Byrsonima coccolobifolia, Eugenia malaccensis, Cerrado, Catepsinas, Catepsins


SANTOS, Marcos Henrique Faleiros. Estudo químico e avaliação biológica das espécies Byrsonima coccolobifolia Kunth. (malpighiaceae) e Eugenia malaccensis L. (myrtaceae). 2013. 109 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Catalão, 2013.