Estudo químico e avaliação biológica das espécies Byrsonima coccolobifolia Kunth. (malpighiaceae) e Eugenia malaccensis L. (myrtaceae)
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Data
2013-07-26
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Universidade Federal de Goiás
Resumo
The study described in this work contributed
to the chemical and biological knowledge of species B. coccolobifoliaand E.
malaccensis,known popularly as "murici" and "jambo-vermelho", respectively.
These species are found in various regions of Brazil, especially in Cerrado
areas, and are widely appreciated by ediblefruit. Several applications in folk
medicine are related to these species,such as antibacterial activity,
antidiarrheal, anti-inflammatory and on control diabetes (antidiabetic). The study
of roots ethanolic extract of B. coccolobifolialed to the identification of mixture
of triterpenes α-amiryn and β-amiryn, mixture of steroids campesterol,
stigmasterol and β-sitosterol, oleanolic acid(olenene-type triterpene) and
glochidonol (lupane-type triterpene), reported for the first time in the Byrsonima
genus. Of the leaves ethanolic extract of E. malaccensiswas possible to isolate
two flavonoids, mearnsetin and mearnsitrin, both of flavonol class. The
structural identification was carried out on the basis of 1D- and 2D-NMR
experiments, GC/MS and comparison with literature data. It was also measured
the inhibition potential of extracts and your fractions of these plants against
cathepsins K, V and L. These enzymes are found mainly in lysosomes and may
also involved in selective and controlled pathological processes, such as
cardiovascular diseases, osteoporosis, atherosclerosis, malignant, pancreatitis,
many others. The extracts and most partitions showed considerable inhibition
against cathepsins (concentration of 125 and 50 µg/mL), and the best results
are observed for cathepsin V. The flavonoids mearnsetin and mearnsitrin have
not presented activity when evaluated in cathepsins K and V (concentration of
25 µM).
Descrição
Palavras-chave
Byrsonima coccolobifolia, Eugenia malaccensis, Cerrado, Catepsinas, Catepsins
Citação
SANTOS, Marcos Henrique Faleiros. Estudo químico e avaliação biológica das espécies Byrsonima coccolobifolia Kunth. (malpighiaceae) e Eugenia malaccensis L. (myrtaceae). 2013. 109 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Catalão, 2013.