Síntese e caracterização estrutural de novas bases de Schiff, a partir dos ácidos 4- e 5-aminossalicílico
Carregando...
Data
2016-02-25
Autores
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Federal de Goiás
Resumo
Schiff bases are imine compounds with wide applications in several are as of knowledge,
highlighting mainly in the biology fields, especially for antimicrobials applications. The synthesis
of six new Schiff bases (SB) are displayed. They were obtained from the direct condensation
methanolic solutions of drugs already actives (4- and 5-ASA) with different aldehydes. The
synthesized compounds were characterized as to their fusion point, solubility, CHN elementary
analysis, infrared absorption spectroscopy, ultraviolet visible spectroscopy and nuclear magnetic
resonance of hydrogen. The synthesized products were evaluated in bioassays on E. coli, S. aureus
and P. aeruginosa strains. The nature of the characterized compounds class confirms the acquired
products as objectified. Two biological results were obtained, as the analyzed variable, the
composition of the prepared stock solution. With DMF, the results were biased, from which
nothing can be stated because of the possibility of influencing as a false positive result. The other
results using DMSO stock solution exhibited a positive prospect regarding the MIC values, with
special attention to the BS6 and BS9 ligands wich showed better activity.
Descrição
Palavras-chave
Bases de Schiff, Ácido 4-aminosalicílico, Ácido 5- aminosalicílico, Agentes antimicrobianos, Schiff bases, 4-amino salicylic acid, 5-aminosalicylic acid, Antimicrobial agents
Citação
LIMA, F. C. Síntese e caracterização estrutural de novas bases de Schiff, a partir dos ácidos 4- e 5-aminossalicílico. 2016.115 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Catalão, 2016.