Síntese e caracterização estrutural de novas bases de Schiff, a partir dos ácidos 4- e 5-aminossalicílico

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Universidade Federal de Goiás


Schiff bases are imine compounds with wide applications in several are as of knowledge, highlighting mainly in the biology fields, especially for antimicrobials applications. The synthesis of six new Schiff bases (SB) are displayed. They were obtained from the direct condensation methanolic solutions of drugs already actives (4- and 5-ASA) with different aldehydes. The synthesized compounds were characterized as to their fusion point, solubility, CHN elementary analysis, infrared absorption spectroscopy, ultraviolet visible spectroscopy and nuclear magnetic resonance of hydrogen. The synthesized products were evaluated in bioassays on E. coli, S. aureus and P. aeruginosa strains. The nature of the characterized compounds class confirms the acquired products as objectified. Two biological results were obtained, as the analyzed variable, the composition of the prepared stock solution. With DMF, the results were biased, from which nothing can be stated because of the possibility of influencing as a false positive result. The other results using DMSO stock solution exhibited a positive prospect regarding the MIC values, with special attention to the BS6 and BS9 ligands wich showed better activity.



Bases de Schiff, Ácido 4-aminosalicílico, Ácido 5- aminosalicílico, Agentes antimicrobianos, Schiff bases, 4-amino salicylic acid, 5-aminosalicylic acid, Antimicrobial agents


LIMA, F. C. Síntese e caracterização estrutural de novas bases de Schiff, a partir dos ácidos 4- e 5-aminossalicílico. 2016.115 f. Dissertação (Mestrado em Química) - Universidade Federal de Goiás, Catalão, 2016.